What is the role of exercise in inflammatory disease prevention and management?

Chris Thomas Schotzko, Shawn Simonson


Background: The average contemporary lifestyle is largely comprised of inactivity and poor nutrition, which has been suggested as a generator of low-grade chronic inflammation. This type of persistent inflammation has become closely associated with numerous non-communicable diseases such as atherosclerosis and type 2 diabetes. Purpose: The primary purpose of this article is to examine the role inactivity plays in low-grade chronic inflammation and the optimal exercise program for reducing inflammation. Findings: A growing body of evidence suggests that the associated pro-inflammatory cytokine signaling is disrupting normal biological processes producing diseases at an alarming rate. In order to stave off or manage these ailments, physical activity has been identified as a viable option for mitigation. However, inappropriate intensities or durations may not mitigate and in some instances, may promote inflammation. Conclusions: In order to be beneficial, patients and healthcare professionals may be well served by using light to moderate exercise routines and modest progressions.


Chronic inflammation; Physical inactivity; Cytokines; C-reactive protein; Disease; Adipose tissue

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ISSN: 19206216